The influence of mifepristone combined with Guizhifuling capsule on the serum VEGF and MMP-9 in the treatment of patients with endometriosis

Abstract

Objective To analyze mifepristone combined with Guizhifuling capsule on serum vascular endothelial growth factor (VEGF) in patients with uterine endometriosis postoperative and matrix metalloproteinase-9 (MMP-9) effect.Methods 76 endometriosis patients were treated with operation,postoperative according to randomly divided into the control group(36 cases) and the observation group(36 cases).The control group was treated with mifepristone,the observation group was treated with mifepristone combined with Guizhifuling capsule.The changes of serum VEGF and MMP-9 and the clinical curative effect were compared between the two groups.Results The effect rate of the observation group was 94.4%,which was higher than 83.3 % in the control group(x2 =4.16,P ＜ 0.05).The observation group after treatment,serum VEGF and MMP-9 were (103.5 ± 22.6) ng/L,(861.4 ± 201.4) ng/L,the control group were (196.2 ± 20.2) ng/L,(1 062.1 ± 274.3) ng/L,the two groups after treatment the serum VEGF and MMP-9 were significantly lower than those before treatment (t =6.346 2,4.327 4,7.624 4,3.916 2,all P ＜ 0.05),compared with the control group,the observation group decreased significantly (t =2.7246,2.9244,all P ＜ 0.05).Conclusion Mifepristone combined with Guizhifuling capsule can improve endometriosis patients by reducing the expression of VEGF and MMP-9. Key words: Endometriosis; Mifepristone ; Guizhifuling capsule ; Vascular endothelial growth factor; Matrix metalloproteinase-9