The influence of fasudil on plasma H2S and NT-proBNP in patients with chronic pulmonary heart disease

Abstract

Objective To explore the influence of fasudil on plasma hydrogen sulfide（H2S）and N-terminal B-type natriuretic peptide（ NT-proBNP） in patients with chronic pulmonary heart disease.Methods According to the digital table,102 patients with chronic pulmonary heart disease were randomly divided into the observation group and the control group, each group in 51 cases.The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated through the conventional treatment plus fasudil. They were treated for 14 days.The mean pulmonary artery pressure（ MPAP） ,plasma H2 S and NT-proBNP were detec-ted.Results After treatment,the total effective rate in the observation group was 96.1%,which was higher than 86.3%in the control group（χ2 =4.046,P〈0.05）.MPAP in the two groups of patients were significantly decreased, and the observation group decreased more significantly than the control group（t=7.246,P〈0.05）.After treatment, plasma H2S were significantly higher,and the observation group increased more significantly（t=2.856,P〈0.05）, plasma NT-proBNP in two groups after treatment were significantly reduced,and the observation group decreased sig-nificantly（t=10.706,P〈0.05）.Conclusion Fasudil can be significantly improved plasma H2S and NT-proBNP in patients with chronic pulmonary heart disease. Key words: Pulmonary Heart Disease Fasudil Hydrogen sulfide Atrial B-type Natriuretic Factor