Abstract
Infections following treatment of rheumatic diseases are common and potentially life threatening. Severe infections may be related to the overall susceptibility in rheumatic diseases, neutropenia in connective tissue diseases, as well as secondary hypogammaglobulinemia (SHG) due to the use of immunosuppressants. Herein, a case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with recurrent cytomegalovirus (CMV) infections and SHG was described, followed by discussion of pathophysiology, clinical presentation, risk factors, and management of SHG, emphasizing the importance of baseline immunoglobulin level monitoring.
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