Abstract
Objective To study the differences of tumor necrosis factor-α in different gestational period placentas and aging placentas and to analyze its significances. Methods Using immunohistochemistry to detect the expression and distribution of tumor necrosis factor-α in different gestational period placentas and aging placentas. Results The expression of tumor necrosis factor-α was significantly higher in the third trimester of pregnancy placentas and aging group than in the first trimester of pregnancy placentas(P＜0.05),and than in the second trimester of pregnancy placentas(P＜0.05).The expression of tumor necrosis factor-α had no significant difference between the third trimester of pregnancy placentas and aging group(P＞0.05). Conclusion TNF-α should play an important role in placental aging. Key words: Placenta aging; TNF-α; TNF-R
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