The efficacy and safety of clopidogrel combined with aspirin in the treatment of transient ischemic attack

Abstract

Objective To observe the efficacy and safety of clopidogrel combined with aspirin in the treatment of transient ischemic attack (TIA). Methods 116 cases of transient ischemic attack were selected from February 2015 to February 2017 in our hospital and were divided into control group and study group, 58 cases in each group. The control group took oral aspirin for treatment, and the study group took oral aspirin and clopidogrel for treatment. Evaluated the efficacy and safety of the two groups. Results 3 weeks after treatment, the clinical effective rate in the control group was 77.59%, less than 94.83% in the study group; blood plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, platelet aggregation rate in the control group were (1.77±0.19)mPa•s, (6.99±0.82)mPa•s, (11.79±1.25)mPa•s, (45.17±7.85)%, higher than those in the study group [(1.36±0.14)mPa•s, (5.14±0.44)mPa•s, (9.26±1.22)mPa•s, (32.88±6.01)%], with statistically significant differences (P 0.05). Conclusion In patients with transient ischemic attack, the effect of clopidogrel and aspirin combination therapy is remarkable, which can effectively enhance the clinical effect, reduce the occurrence of ischemic cerebral apoplexy, improve prognosis, with good security. Key words: Transient cerebral ischemia; Clopidogrel; Aspirin; Curative effect; Security