Effect of aspirin combined with clopidogrel in the treatment of transient ischemic attack and its influence on coagulation function

Abstract

Objective To investigate the effect of aspirin combined with clopidogrel in the treatment of transient ischemic attack(TIA), and its influence on blood coagulation. Methods Ninety-six patients with TIA were selected and divided into observation group and control group by random number table method, with 48 cases in each group.The control group was treated with aspirin, and the observation group was treated with aspirin and clopidogrel.The treatment effect, coagulation index changes and adverse reactions were compared between the two groups. Results The effective rate of the observation group was 91.67%(44/48), which was higher than 68.75%(33/48) of the control group (χ2=7.941, P 0.05). Conclusion The curative effect of aspirin combined with clopidogrel is superior to aspirin alone in the treatment of TIA, and it can improve the coagulation function of patients, which has high security. Key words: Aspirin; Clopidogrel; Ischemic attack, transient; Fibrinogen; Prothrombin time; Activated partial thromboplastin time