Efficacy and mechanism of clopidogrel combined with aspirin in the treatment of transient ischemic attack

Abstract

Objective To study the efficacy and mechanism of sequential therapy of clopidogrel combined with aspirin in the treatment of transient ischemic attack. Methods 150 cases with transient ischemic attack were set as the research subjects. According to the random number table method, they were divided into aspirin group, clopidogrel group and combination group. The clopidogrel group was treated with 75mg clopidogrel, once daily. The aspirin group was treated with 50mg aspirin, twice a day. The combined group was treated with 300mg clopidogrel + 300mg aspirin at the first day, 75mg clopidogrel + 100mg aspirin at the second day. Three groups were treated for a period of 15 days. After 15d treatment, the raw fiber protein (FIB), two D dimer (D-D), activated partial thromboplastin time (APTT) and prothrombin time (PT) of three groups and adverse reactions, curative effect and recurrence rate were analyzed. Results After treatment, the FIB, D-D, APTT and PT of the combined group were (3.14±0.24)g/L, (0.61±0.26)mg/L, (33.58±2.77)s, (15.67±0.72)s, which of the clopidogrel group were (3.32±0.25)g/L, (0.91±0.32)mg/L, (30.19±2.19)s, (15.64±0.78)s, which of the aspirin group were (3.40±0.22)g/L, (1.02±0.39)mg/L, (29.71±2.21)s, (13.21±0.80)s, which were significantly improved than before treatment[the combination group (3.59±0.26)g/L, (2.50±0.35)mg/L, (27.53±2.41)s, (11.23±0.69)s; the clopidogrel group (3.58±0.28)g/L, (2.51±0.40)mg/L, (27.19±2.53)s, (11.73±0.82)s; the aspirin group (3.61±0.27)g/L, (2.46±0.32)mg/L, (27.61±2.13)s, (11.68±0.77)s], the effect of the combined group was better than that of the clopidogrel group and aspirin group (F=8.12, P<0.05). The total effective rate of the combination group (96.00%) was significantly higher than that of clopidogrel group (84.00%) and aspirin group (76.00%), the differences were statistically significant (χ2combination group vs. clopidogrel group=4.00, χ2combination group vs. aspirin group=8.31, all P<0.05). The adverse reactions in the three groups had no difference, but the recurrence rate of the combination group (8.00%) was significantly lower than that of the clopidogrel group (24.00%) and the aspirin group (28.00%), the differences were statistically significant (χ2combination group vs. clopidogrel group=4.76, χ2combination group vs. aspirin group=6.78, all P<0.05). Conclusion The combination of clopidogrel and aspirin in the treatment of transient ischemic attack has significant effect and low recurrence rate, which is worthy of popularizing widely. Key words: Ischemic attack, transient; Clopidogrel; Aspirin