Abstract
The effects of stilbestrol and quinestrol on blood coagulation and f ibrinolysis were studied during the puerperium. Stilbestrol significant ly (p less than .05) increased Factors IX and X during the 1st week of the puerperium though levels returned to normal by the 6th week after delivery. Quinestrol significantly increased Factors II (p. less than .01) IX (p. less than .02) and X (p less than .05) during the 1st week of the puerperium. Factor II values remained significantly higher 6 weeks after delivery (p less than .01). During the 1st week of the puerperium plasma antithrombin levels were significantly lower in stilbestrol patients (p less than .02). Plasma antithrombin III levels were significantly lower in estrogen-treated patients 6 weeks after delivery (p less than .05). There were no marked increases in serum antithrombin III levels in any of the groups. Stilbestrol and quinestrol increased concentrations of plasminogen and antiplasmin during the 1st week of the puerperium. Quinestrol patients had significantly elevated levels of plasminogen and antiplasmin 6 weeks after delivery (p less than .01). The results suggest that the inhibition of lactation by estrogens may pose an increased thrombogenic risk.
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