Abstract
The effect of monoaminergic (DOPA, metamphetamine, propylhexedrine) and cholinolytic agents (atropine, biperiden, caramiphen, trihexyphenidyl) on spinal motor control disturbed by physostigmine and tetrabenazine was studied in the rat. In addition the anticonvulsant agent phenytoin was included in the investigation. Physostigmine and tetrabenazine produced rigidity, increased α reflex discharge, shortened the latency of α reflex discharge and decreased γ reflex discharge. Rigidity as well as the action of physostigmine and tetrabenazine on α motor activity were inhibited by the drugs. The results are in accordance with the hypothesis that parkinsonlike rigidity in the rat results from hyperactivity of the α motor system, which is due to an imbalance between monoaminergic and cholinergic mechanisms in the brain.
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