Abstract
The effect of amantadine (hydrochloride and sulphate) on the rigidity produced by reserpine and oxotremorine was studied in rats. Amantadine abolished the rigidity and the changes in alpha reflex activity brought about by reserpine and oxotremorine. In animals given these drugs it depressed alpha hyperactivity and increased the latency between stimulus artifact and the first alpha reflex discharge. Gamma activity reduced by reserpine was increased by amantadine. The increase in gamma activity observed after oxotremorine was not reduced. Amantadine given alone increased alpha reflex discharges, but did not change the latency between stimulus artifact and the first alpha discharge or gamma reflex discharges. Amantadine hydrochloride and amantadine sulphate did not differ in their action on rigidity and spinal motor control.
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