Abstract
The isolated perfused central vein of the rabbit ear constricts in response to approximately 0.5 ng of BK or kallidin injected into the perfusion flow of 10 ml/min. Constrictor responses are also elicited by several other substances including catecholamines and histamine but none approach the potency of the plasma kinins. This relative specificity together with the steep dose-response curve for kinins makes it an eminently suitable preparation for bioassay of these peptides. Rabbit veins from other sites do not have the same pattern of reactivity and no generalization is possible from these data to veins in vivo.
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