The effect of creatine phosphate combined with salvia miltiorrhiza polyphenols acid salt in treatment of coro-nary heart disease with heart failure

Abstract

Objective To explore the effect of creatine phosphate combined with salvia miltiorrhiza polyphe-nols acid salt in treatment of coronary heart disease heart failure. Methods 114 cases of patients with coronary heart disease heart failure were selected as research objectives, who were treated in our hospital from August 2012 to August 2014. And they were randomly divided into control group(55 cases)and research group(59 cases)according to the number table method. Routine therapy of heart failure were given in both groups and the research group were added creatine phosphate combined with salvia miltiorrhiza polyphenols acid salt. The clinical efficacy of two groups of patients were observed and compared. Results The total effective rate in research group was 96.61%(57／59), significantly higher than 85.45%(47／55)in control group, the difference was statistically significant(χ2＝4.427,P＝0.035). Before treatment, the left ventricular ejection fraction(LVEF), left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter(LVESD)and 6min walking distance between two groups had no sig-nificant difference(P＞0.05). After treatment, the LVEDD and LVESD of research group were decreased and LVEF and 6 minutes walking distance of two groups were increased, the difference was statistically significant(P＜0.05), the LVEDD and LVESD of research group were lower than that of the control group and LVEF and 6 minutes walking distance were higher than that of control group, the difference was statistically significant(P＜0.05). No complications or side effects related to the treatment were found in both groups. Conclusion On the basis of routine therapy of heart failure, the effect of creatine phosphate sodium combined with salvia miltiorrhiza polyphenols acid salt in treat-ment of coronary heart disease heart failure can improve cardiac function of the patients with the indicators, and the clinical effect is obvious,and side effects is rarely observed. Key words: Coronary heart disease heart failure; Salvia miltiorrhiza polyphenols acid salt; Creatine phosphate