Effect of Carvedilol on diabetic patients with heart failure

Abstract

Objective To observe the effect of Carvedilol on cardiac function and blood lipids,blood glucose,insulin resistance in diabetic with coronary heart disease heart failure. Methods 60 patients with heart failure due to type 2 diabetes mellitus and coronary heart disease were randomly divided into two groups : control group 30 cases and treatment group 30 cases. All the patients were checked with index of left ventricular end diastolic diameter (LVEDD), end-systolic diameter (LVESD), ejection fracture(LVEF), blood lipids, concentration of fastplasma glucose(FPG) ,fast insulins(FINS) and HOMA-IR were observed 1 year after treatment. Results The cardiac function after treatment was significantly higher than that before treatment( X2 =3. 12,P＜0. 05) ;The level of LVEF(0. 50±0. 08) % significantly higher than before treatment ( 0. 37±0.07 ) % (t = 2. 377, P＜0. 05 ). The level of LVEDD (50. 74±2. 05 ) mm, LVESD ( 32. 17±2. 32 ) mm in treatment group were significantly lower than before treatment (62. 35±4. 62 mm ,41.22±2. 54 mm) (t = 2. 367, t = 2. 289, P＜0. 05 ) ; The level of LVEF ( 0. 50±0. 08 ) % in treatment group was higher than control group(0. 45±0. 06)% (t =2. 357 ,P＜0. 05) ;The level of LVEDD;LVESD (50. 74±2. 05 mm,32. 17±2. 32 mm) in treatment group were lower than the control group(61.45±3.72 mm,39. 32±1.91 mm) (t = 2. 217,t = 2. 319 ,P＜0. 05 );The level of C-reactive protein(7.56±3. 25 ) mg/L in treatment group were lower than before treatment (10. 99±4. 26)mg/L(t = 2. 317, P＜0. 05 ). Conclusion Carvedilol could reverse ventricular remodeling and improve cardiac function and blood sugar metabolism in diabetic with coronary heart disease heart failure. Key words: Carvedilol; Diabetes Mellitus; Coronary disease; Heart failure; Congesfive