Abstract
Summary Background & aims Vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular postpartum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. The intervention group received an intramuscular injection of 300,000 IU of vitamin D during 3–10 days after their child delivery, but controls did not. Serum 25-hydroxyvitamin D, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and serum adiponectin were measured at baseline and after 3 months of intervention. Results Serum 25 OH vitamin D increase significantly in the intervention but not in the control group from 24.25 to 62.10 (nmol/L) (p-value Conclusions The 300,000 IU single dose of intramuscular injection of vitamin D is regarded as an effective procedure to improve vitamin D status which significantly increased the adiponectin levels among mothers with gestational diabetes after delivery.
Highlights
Vitamin D has been widely confirmed to improve the bone mineralization and calcium homeostasis [1]
Many studies have shown that vitamin D levels are negatively associated with type 2 diabetes and insulin resistance in children and adults [7]; vitamin D could play an important role in the pathogenesis of gestational diabetes mellitus (GDM) via affecting either insulin sensitivity or b-cell function or even both of them [8e10]
It has been proved that every 5 ng/mL decrease in serum vitamin D level is associated with a 1.29-fold increase in the risk of GDM [12]; systematic review articles have highlighted the improvement in insulin sensitivity via greater serum vitamin D concentrations [8,9,13]
Summary
Vitamin D has been widely confirmed to improve the bone mineralization and calcium homeostasis [1] It is being increasingly recognized for its important non-skeletal functions including endocrine and physiological actions [2,3]. Many studies have shown that vitamin D levels are negatively associated with type 2 diabetes and insulin resistance in children and adults [7]; vitamin D could play an important role in the pathogenesis of gestational diabetes mellitus (GDM) via affecting either insulin sensitivity or b-cell function or even both of them [8e10]. This study investigated if a single, large, intramuscular postpartum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. Serum 25hydroxyvitamin D, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and serum adiponectin were measured at baseline and after 3 months of intervention
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