The correlation between newborns and pregnant women measles antibody level and the regularity of the change of newborns antibody with time

Abstract

Objective To analyze the correlation between newborn and mother's measles antibody level and the regularity of the change of newborn antibody with time. Methods Prenatal venous blood and newborns′ umbilical cord blood of 127 pregnant women in the Eighth People's Hospital of Qingdao were collected, and venous blood of 3-month-old in 79 cases, 6-month-old in 72 cases and 9-month-old in 57 cases of newborns were followed up.The level of measles IgG antibody was detected by enzyme-linked immunosorbent assay. Results The geometric mean concentration of the maternal measles antibody was (639.56±3.15)mIU/mL, which was significantly lower than that of the neonatal blood antibody concentration [(1 102.46±2.86)mIU/mL](P<0.05). The geometric means of neonatal measles antibody in 3, 6, 9 months old newborns were (159.95±3.25)mIU/mL, (126.35±4.06)mIU/mL, (113.04±4.32)mIU/mL respectively, which were significantly lower than those of the newborn at birth(all P<0.05). With the increase of the age, the positive rate and protection rate of the newborn all decreased significantly(all P<0.05). Using trend Chi square test, it was found that the level of measles antibody increased with the increase of measles antibody level(χ2=9.46, P<0.05). Pearson correlation analysis showed that the logarithmic level of maternal blood antibody was closely correlated with the umbilical cord blood(r=0.78), 3-month-old(r=0.54), 6-month-old(r=0.47), 9-month-old(r=0.53) blood antibody logarithm level(all P<0.05). Univariate analysis showed that the geometric mean of neonatal measles antibody was significantly correlated with neonatal sex, delivery mode, gestational age, birth weight and maternal age(all P<0.01). Conclusion With the increase of time, the measles antibody gradually attenuates, and the level of antibody is closely correlated with the level of maternal antibody.Therefore, we should actively implement measles vaccination for women of childbearing age, and adopt a way to improve maternal antibody concentration to increase the concentration of neonatal measles antibody, so as to prevent or reduce measles in infants. Key words: Measles; Antibodies; Newborns; Mothers