Investigation on the measles antibody level in healthy population in Xicheng district, Beijing

Abstract

Objective To identify the level of measles antibody in healthy population,and provide scientific immunization strategy for the elimination of measles.Methods The subjects who had been living for over 6 months in Beijing were recruited for this study.Pps sample method was used to select 220 objects from 10 age groups.Demographic characteristics,vaccine immunization were investigated by questionnaire.The measles IgG antibody was measured by ELISA assay.Results Positive rate against measles antibody was 85.91％.Median of antibody was 976 IU · l-1.Positive rate and median of measles antibody were significantly different between population from different age groups(x2 =42.39,P ＜0.01 ;H =38.84,P ＜0.01).Antibody positive rate and median were lowest in the ＜ 8 month age group,which were separately 21.43％,120 IU · l-1 ;and highest in the 1-4,5-9 and ＞40 year age group,their positive rate all reach 95.45％ and median were separately 3059 IU · l-1,2099 IU · l-1,2308 IU · l-1.The range of antibody positive rate and median in other year group were 72.73％ ～95.45％ and 512 ～ 1679 IU · l-1,respectively.Antibody positive rate and median in population without vaccination history were lower than those population with vaccination history and people whose history unknown.The difference showed statistical significance (x2 =28.73,P ＜ 0.01 ;H =1.56,P ＜ 0.01).Conclusions Among the persistent population in Beijing,measles antibody level among the children ag(1-9 years old) was high enough to prevent outbreak and epidemic of measles.However,we should try our best to strengthen the measles antibody level among the babies younger than 8 month and population aging between 15 and 40 years old. Key words: Measles; Antibody; Vaccines; Immunity