Monitoring of measles, rubella, mumps and varicella antibody levels in healthy people in Zhoushan

Abstract

Objective To understand the immunization status of measles, rubella, mumps and varicella in healthy population in Zhoushan, and to provide the basis for immunization strategy. Methods Normal people in Zhoushan were divided into 8 age groups (0-4, 5-9, 10-14, 15-19, 20-29, 30-39, 40-49 and 50-60 years old) , and over 200 serum samples were chosen for each age group. The IgG antibody of measles, rubella, mumps and varicella were detected by ELISA, and the positive rates and geometric mean concentration (GMC) of antibody were calculated. Results The total antibody positive rates of measles and rubella in total population were 88.56% and 81.61%, and the total antibody positive rates in 40-49 age group were both the lowest (80.75% and 72.75%) . The differences of measles IgG antibody positive rates, GMCs and protective antibody positive rates in each age group had statistical significance (χ2=42.696, F=41.341, χ2=179.160, P all <0.01) . The total antibody positive rate of mumps was 88.77%, and the total antibody positive rate and GMC in 10-14 age group were both the lowest (71.18% and 200.51 U/mL) . The total antibody positive rate of varicella was 82.24%, and the total antibody positive rate and GMC in 0-4 age group were both the lowest (52.51% and 82.72 mIU/mL) . Conclusions In Zhoushan area, the immunity levels of measles and rubella are relatively high, but the levels in middle-aged population are low. The immunity level of mumps in 10-14 age is relatively low. It is necessary to propagandize the varicella vaccine according to the lower immunity level compared with other 3 diseases. Key words: Measles; Rubella; Mumps; Varicell; Immunity