Levels of antibody to measles, rubella and mumps viruses in a healthy population in Sichuan province in 2018

Abstract

Objective To investigate the levels of antibody to measles, rubella and mumps viruses in healthy population in Sichuan province, 2018. Methods Totally 1 901 healthy people were selected from 7 age groups in 9 counties of Sichuan province. Serum samples of them were collected to test the IgG antibody to measles, rubella and mumps viruses by enzyme-linked immunosorbent assay (ELISA), and analyzed statistically. Results In 1 901 subjects, the positivity rates of measles, rubella and mumps IgG antibody were 83.69%, 71.59%, 63.12% respectively, and the geometric mean titer (GMCs) were 1 289.92 mIU/ml, 87.63 IU/ml, and 425.62 U/ml respectively. There were significant differences in positivity rates of measles, rubella and mumps antibody among age groups and counties. There were no significant differences in GMCs of measles antibody among age groups and among counties, and the samples with full protection of measles (GMC≥1 000 mIU/ml) accounted for only 34.19%. There were significant differences in GMCs of rubella and mumps antibody among age groups and among counties. Conclusions The levels of antibody to measles, rubella and mumps were lower in healthy population in Sichuan. Vaccination should be strengthened in vulnerable areas and age groups. Key words: Measles; Rubella; Mumps; Antibody levels