The comparison of curative effect of aerosol inhalation between asarone and ambroxol hydrochloride in pulmonary infection

Abstract

Objective To compare the curative effect on pulmonary infection between asarone and mucosolvin. Methods 99 cases with pulmonary infection were randomly divided into A,B,C three groups with each group of 33 patients according to the order of admission. On the basis of conventional therapy, A group were received the ultrasonic nebulization therapy of asarone plus 0.9% sodium chloride injection, B group were received the ultrasonic nebulization therapy of mucosolvin plus 0.9% sodium chloride injection,C group was treated based on the control group received the ultrasonic nebulization therapy of chemotropism plus 0.9% sodium chloride injection treatment. The time of cough and anhelation turnaround, the time of body temperature returned to normal, the time of pulmonary rales disappearance and hospitalization time. The curative effects were judged at the end of treatment. Results After treatment, A group of cough, shortness of breath disappearance time, temperature returned to normal time, hospital stay, pulmonary rales disappearance time was(4.30±1.55)d,(2.93±0.89)d,(4.44±1.67)d,(5.66±1.72)d,respectively,in group B(4.34±1.83)d,(3.10±0.77)d,(4.52±1.58)d,(5.82±1.76)d,C group were(6.11±1.49)d,(3.98±1.01)d,(6.22±1.92)d,(7.52±1.56)d,A,B groups cough, shortness of breath disappear time, body temperature returned to normal, pulmonary rales disappeared time and hospital stay were not significantly different(all P> 0.05),A group of cough, shortness of breath disappearance time, body temperature returned to normal, pulmonary rales disappeared time, length of hospital stay were significantly shorter than group C(t= 4.836,4.481,4.018,4.601,all P< 0.05),B groups cough, shortness of breath disappear time,pulmonary rales disappeared time, length of hospital stay were significantly shorter than those of group C(t= 4.309,3.980,3.927,4.152,all P<0.05);A group and B group total efficiency of 90.9% and 87.8%,respectively, which were significantly higher than 69.7% group C (χ2= 26.753,24.685,P= 0.000),A group and B group total efficiency difference was not statistically significant (χ2= 1.128,P= 0.288). Conclusion Asarone and mucosolvan have the similar curative effect in the treatment of pulmonary infection. It should be combined with the specific situation of patients to choose drugs in clinical practice. Key words: Pulmonary infection; Asarone; Mucosolvan