The clinical value of serum sialic acid and lactadherin in the prognosis evaluation of atherosclerotic heart disease

Abstract

Objective To discuss the effect and clinical value of serum sialic acid (SA)and lactadherin(MFG-E8)in the coronary atherosclerotic heart disease(CHD). Methods Selected 295 patients who visited to Wuhan University Renmin's Hospital cardiovascular medicine (from January to June, 2014), and then according to the results of coronary angiography divide the subjects into control group(n=78, the result of coronary angiography completely normal)and coronary heart disease group(n=217, the results of coronary angiography showed that one major coronary stenosis was more than 30%). Detected their serum level of lipid, SA, MFG-E8, hs-CRP index. At last, analyze the differences of SA and MFG-E8 between these groups, and the correlation with the severity of coronary stenosis (symbolize with Gensini score), use the binary logistic regression analysis to research the relationship among the serum level of SA, MFG-E8 and the risk of CHD. Results Compared with the control group, the patients with CHD have a higher level of serum SA and a lower level of MFG-E8 (U=4 402.5, 2 736.0 respectively, P<0.001); the AMI group has a higher level of serum SA than the StA and UA groups (U=1 329.0, 957.5 respectively, P<0.001); the AMI group has a lower level of serum MFG-E8 than the StA groups (U=1517.0, P<0.001). The spearman correlation analysis showed that the serum SA has a positively correlation with the level of TG, hs-CRP and Gensini score, and has a negatively correlated with the level of MFG-E8(r=0.214, 0.462, 0.378, -0.322 respectively, P<0.01); the MFG-E8 has a negatively correlated with the level of TG, hs-CRP and Gensini score (r=-0.18, -0.425, -0.564 respectively, P<0.01). Binary logistic regression analysis showed that there was a positive correlation between the serum SA and the risk of CHD (OD= 4.782, 5.319, 4.179 3.832, 3.648 respectively, P<0.001), and the was a negative correlation between the serum MFG-E8 and the risk of CHD (OD= 0.118, 0.112, 0.127, 0.135, 0.134 respectively, P<0.001). Conclusion With the serum SA rised and the MFG-E8 reduced, the risk of coronary heart disease was higher, combined detection these two indexes may be able to diagnose the CHD and assess the degree of stenosis and the risk of CHD.(Chin J Lab Med, 2015, 38: 746-750) Key words: Coronary disease; N-acetylneuraminic acid; Milk proteins; C-reactive protein; Risk factors