Abstract
Objective The study focused on the relationship between neopterin （NP）, Gensini score and high-sensitivity C-reactive protein (hs-CRP) to explore the important role of the neopterin in patients with coronary heart disease. Methods Total of 442 patients, admitted to the Department of Cardiology at Renmin Hospital, Wuhan University from January 2012 to September 2012, were enrolled in this study. There were 176 patients in the control group and 266 patients with coroary disease in the experimental group. The Gensini score was used to assess the severity of the coronary lesions in the patients with coronary heart disease. The enzyme-linked immunosorbent assays (ELISAs) were used to measure the serum NP level. The other indicators were assessed by use of fully automatic biochemical and coagulation analyzers. The data were analyzed by using of SPSS19.0. T-test was used for analysis of the results between the control group and the experimental group. One-factor analysis variance (ANOVA) was used for comparisons of the results among the 3 groups, and Spearman correlation analysis was used for the correlation analysis between the NP level and Gensini score as well as hs-CRP level. Results The serum NP level was higher in the experimental group than that in the control group ［(1.99±0.37) vs （1.48±0.29） ng/ml，P<0.05］, and the NP level was positively correlated with the severity of coronary heart disease. Compared with the stable angina (SA) group, the serum NP level was significantly increased in the unstable angina (UA) group (2.00±0.37)ng/ml and the acute myocardial infarction (AMI) group (2.10±0.43) ng/ml (t=2.38，P<0.05). In addition, the serum NP level was positively correlated with the Gensini score (r=0.687,P<0.001) as well as with the level of hs-CRP (r=0.190,P<0.001). Conclusions The serum level of NP was significantly higher in patients with coronary heart disease and was positively correlated with the severity of coronary artery disease. Thus, NP may become a new indicator for the assessment of the inflammatory response in coronary atherosclerosis.（Chin J Lab Med,2014,37:513-516） Key words: Coronary disease; Neopterin; Biological markers
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