Abstract
Objective To explore the clinical value of N-terminal prosoma of B-type natriuretic peptide (NT-ProBNP) in assessing the heart function of the patients with chronic heart failure.Methods 94 inpatients diagnosed as chronic heart failure were divided into 4 groups (Ⅰ,Ⅱ,Ⅲ,Ⅳ) according to the cardiac function of NYHA Functional Class(NYHA-FC),and 5 inpatients with normal cardic function were also selected as control group.The plasma NT-ProBNP was detected.The results of heart color ultrasound was collected.Results In patients with heart failure,left ventricular end-diastolic dimension(LV) increased following the increase of plasma NT-ProBNP level.Among NYHA-FC groups,NT-ProBNP levels were different,which increased as the NYHA-FC upgrades.Spearman correlation analysis showed that NT-ProBNP had good correlation with both LV and NYHA-FC(r =0.453,P ＜0.01 ;r =0.538,P ＜ 0.01).There was also good correlation between LV and NYHA-FC(r =0.322,P ＜ 0.01) ;but the correlation was slightly lower than the previous.Conclusion NT-ProBNP can reflect the level of ventricular remodeling and the severity of the cardiac decompensation in chronic heart failure patients. Key words: Heart failure; NT-ProBNP; Left ventricular enddiastolic dimension
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