The Clinical efficacy in the treatment of early diabetic nephropathy from rosuvastatin combined with benazepril

Abstract

Objective To explore the clinical efficacy in the treatment of early diabetic nephropathy from rosuvastatin combined with benazepril. Methods 107 patients of early diabetic nephropathy in our hospital were retrospectively analyzed. On the basis of the conventional treatment of diabetes, the control group were treated with benazepril;while the observation group were treated with rosuvastatin combined with benazepril. Before and after treatment, the improvement of the related indicators were observed, such as blood glucose, lipids and renal function. The clinical efficacy were comprehensively evaluated. Results The level of the fasting blood glucose and 2-hour postprandial blood glucose of the observation group were lower than those of the control group, the difference was significant （ t = 9. 785,9. 525 ,all P 〈0.05） ;the blood lipid levels such as TC,TG and LDL-C in the observation group were significantly lower than those of the control group. But the levels of HDL-c was significantly increased, the difference was significant （ t = 9. 938,10. 283,10. 475,9. 782, allP 〈 0.05 ） ; the indicators of renal function such as UAER, Scr and BUN were significantly lower than those of the control group, the difference was significant（ t = 9. 938,12. 341, 11. 265,9. 982, all P 〈 0.05 ） ; The total effective rate of the observation group was 94.55 %, significantly higher than the 76.92% of the control group, the difference was statistically significant（ x^2 = 10. 120, P 〈 0.05 ）. Conclusion The effect of rosuvastatin combined with benazepril for the treatment of early diabetic nephropathy is very significant which is worthy aoolving in clinical oractice. Key words: Diabetic nephropathy; Rosuvastatin ; Benazepril