The clinical effect of ibuprofen in treatment of severe hand foot mouth disease and its effect on relative cytokines

Abstract

Objective To investigate the clinical effect of ibuprofen in treating severe hand foot mouth disease and its effect on serum IL-6,TNF-αand IL-8. Methods 154 cases of severe hand foot and mouth disease were randomly divided into conventional treatment group and ibuprofen treatment group(each group 77 cases).And 77 cases of hand foot and mouth disease in the same period were admitted as normal control group.,.Two treatment group were given conventional antiviral and symptomatic treatment, ibuprofen treatment group was conducted with application of ibuprofen suspension liquid or drops of oral or nasal feeding. The clinical symptoms and signs, blood biochemical indexes, cerebrospinal fluid index and related cytokines were observed in the ibuprofen treated group and the routine treatment group. Results 72 hours after treatment, the treated with ibuprofen group of body temperature(t= 10.330,P=0.000),respiration(t=2.460,P=0.016),pulse(t=3.200,P=0.002)and blood pressure(Systolic pressure:t=2.000,P=0.049,Diastolic blood pressure:t=4.890,P=5.42)better than the conventional treatment group, cerebrospinal fluid pressure(t=3.330,P=0.001),protein(t=3.370,P=0.001),cell number(t=3.780,P=0.0003) and sugar level(t=3.410,P=0.001)were lower than the conventional treatment group;serum IL-6(t=6.961,P= 1.038),IL-8(t=4.229,P=6.463),and TNF-α(t=2.020,P=0.047)were significantly lower than those of the conventional treatment group,the differences had statistical significance(P<0.05). In addition,the treatment group of ibuprofen was superior to the conventional treatment group in the hot withdrawal time(t=5.210,P=1.59)and average hospitalization days(t=3.090,P=0.003). Conclusion Severe hand foot and mouth disease on the basis of routine treatment plus cloth ibuprofen treatment,is ideal effect, and can regulate the serum IL-6,IL-8,and TNF-α.It is worthy of popularization and application. Key words: Buprofen; Cytokine; Hand-foot-mouth disease