Effect of methylprednisolone combined with immunoglobulin on prognosis of children with severe hand foot mouth disease

Abstract

Objective To investigate the effect of methylprednisolone combined with immunoglobulin on prognosis of children with severe hand-foot-mouth disease. Methods A total of 98 cases of severe hand-foot-mouth disease in Shanxi Children’s Hospital form May 2016 to April 2018 were selected. They were divided into combined group and control group according to the random number table method, with 49 cases in each group. The control group was treated with routine drugs, and the combined group was treated with methylprednisolone combined with gamma immunoglobulin on the basis of the treatment in the control group. The clinical efficacy, immune function, inflammatory reaction and adverse reactions were compared between the two groups. Results The total effective rate in the combined treatment group (79.59%) was higher than that in the control group (51.02%), and the difference was significant (P<0.05). The levels of immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) after treatment in the combined group and the control group were all higher than those before the treatment, and the improvement of the above indexes in the combined group were better than those in the control group, the differences were significant (P<0.05). After treatment, the levels of CT, CRP and WBC in the two groups were significantly lower than those before treatment, and the improvement of the above indexes in the combined group were better than those in the control group, the differences were significant (P<0.05); the incidence of total adverse reaction (6.12%) in the combined group was less than that in the control group (20.41%), and the difference was significant (P<0.05). Conclusions Methylprednisolone combined with immunoglobulin can improve the clinical efficacy on children with hand-foot-mouth disease, which can improve the immune function of the body, reduce the inflammatory response, and have less adverse reactions, and the prognosis of the children is better. Key words: Severe hand-foot-mouth disease; Methylprednisolone; Immunoglobulin; Immune function; Inflammatory response