Abstract
The Areas Under Curves (AUC) used in diabetes research: Update view
Highlights
Application of incremental Area Under Curve (iAUC) in clinical practiceThe iAUC value is applied to calculate the Glycemic Index (GI) of food in nutrition [6]
The Area Under the Curve (AUC) is derived from the Oral Glucose Tolerance Test (OGTT) which is widely used to diagnose the Impaired Glucose Tolerance (IGT) in the clinic
It has been indicated that than original AUC (tAUC) expressed the best correlation with the 2-hour glucose level of oral glucose tolerance test (OGTT) and the total glucose response was represented by the tAUC better than incremental Area Under Curve (iAUC) or positive incremental AUC (pAUC) in a clinical report [5]
Summary
The iAUC value is applied to calculate the Glycemic Index (GI) of food in nutrition [6]. Application of iAUC is going to minimize the difference between individuals. The variations in fasting plasma glucose between healthy subjects are not such critical as diabetic patients. The GI value is calculated as a percentage of the reference food (glucose). The application of iAUC shall be careful, it is suitable to distinguish the change(s) in cases after an acute administration, similar to the postprandial glycemic responses. The variations in fasting plasma glucose between diabetic patients are associated with the pathogenic condition. Fasting plasma glucose is varied mainly with the diabetic progress. Application of iAUC in diabetic patients must keep in mind to conduct the associated factors carefully
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