Abstract

Antihyperglycemic effects of Trigonella foenum-graecum seeds and Cinnamomum zeylanicum bark on key enzymes of carbohydrate metabolism in tissues of rats with experimental diabetes

Highlights

  • Diabetes is a chronic metabolic disorder, prevalent in both developed and developing countries such as India

  • It was observed that oral administration of aqueous suspension of Trigonella foenum-graecum (Tfg) seed and Cinnamomum zeylanicum (Cz) bark powder significantly decreased the blood glucose levels in diabetic rats

  • Results of the present study showed that oral administration of 440 mg/kg, 870 mg/kg, 1740 mg/ kg body weight, Tfg seed powder daily for 14 days, to the diabetic rats caused 3.0%, 6.3% and 16.6% decrease on 7th day while 5.6%, 14.8% and 34.2% decrease in the blood glucose level on day 14th of the start of treatmet

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Summary

Introduction

Diabetes is a chronic metabolic disorder, prevalent in both developed and developing countries such as India. It is a major endocrine disorder that affecting about 10% of the total population all over the world [1]. Diabetes results from insufficient amount or lack of insulin secretion or reduced sensitivity of the tissue to insulin [2,3]. There are several pathogenetic processes which play important role in the development of diabetes because some of them involve killing of beta cells of pancreas with consequent insulin deficiency, and others in resistance to insulin action. People with diabetes can lead an active life by managing the blood glucose level with drugs, insulin as well as by the lifestyle management which including dietary changes and physical activity, in order to prevent complications of disease

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