Abstract
An analysis of radioisotope dilution cardiac output curves yielded 19 parameters which were measured from curves obtained before and after therapeutic manoeuvres in patients such as haemodialysis and the administration of hypotensive drugs. The changes observed in the parameters were consistent with the known pharmacological actions of the compounds. By means of a multiple regression analysis, three variables—central mean transit time, right-heart volume index and the ratio of the dilution curve area to its plateau height—were found which can be used to monitor for changes occurring in the shape of the dilution curve which are consistent with a deterioration of the patient's haemodynamic state.
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