Abstract
Binary orotic acid metal complexes of Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and two mixed metals complexes of (Co(II), Ni(II)) and (Ni(II), Cu(II)) were synthesized and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility, and ESR spectra. The Analysis proved that the ligand has different coordination modes and the complexes were of octahedral, tetrahedral, and trigonal bipyramidal geometries. Molecular modeling techniques and quantum chemical methods have been performed for orotic acid to calculate charges, bond lengths, bond angles, dihedral angles, electronegativity (χ), chemical potential (μ), global hardness (η), softness (σ) and the electrophilicity index (ω). The thermal decomposition of the complexes was monitored by TGA, DTA, and DSC techniques under the N2 atmosphere. The thermal decomposition mechanisms of the complexes were suggested. The biological activity of orotic acid and some of the complexes are tested against antibacterial and antifungal organisms.
Highlights
Vitamin B13 is an orotic acid monohydrate, Figure 1 (2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidine carboxylic acid or uracil-6-carboxylic acid) [1]-[6]
The Analysis proved that the ligand has different coordination modes and the complexes were of octahedral, tetrahedral, and trigonal bipyramidal geometries
Complexes of orotic acid and diaminocyclohexane ligands (DACH) with platinum (II) and palladium (II) ions investigated as potential anticancer agents [18] [19] [20]
Summary
Vitamin B13 is an orotic acid monohydrate, Figure 1 (2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidine carboxylic acid or uracil-6-carboxylic acid) [1]-[6] It is extracted from cow’s milk [7] [8]. Whey and beef [1] It is synthesized from aspartic acid and takes part in the biosynthesis of pyrimidine nucleotides [8] [9]. It is able to coordinate a metal atom through the two N atoms of the pyrimidine ring, two carbonyl oxygen atoms, and a carboxylate group [13] [14] It is manufactured by the body by intestinal flora [15] and it is important for the metabolization of vitamin B6 and vitamin B12 [16] [17]. Complexes of orotic acid and diaminocyclohexane ligands (DACH) with platinum (II) and palladium (II) ions investigated as potential anticancer agents [18] [19] [20]
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