Synthesis, spectral, computational and thermal analysis studies of metallocefotaxime antibiotics

Abstract

Cefotaxime metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and two mixed metals complexes of (Fe,Cu) and (Fe,Ni) were synthesized and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility and ESR spectra. The studies proved that cefotaxime may act as mono, bi, tri and tetra-dentate ligand through oxygen atoms of lactam carbonyl, carboxylic or amide carbonyl groups and nitrogen atom of thiazole ring. From the magnetic measurements and electronic spectral data, octahedral structures were proposed for all complexes. Quantum chemical methods have been performed for cefotaxime to calculate charges, bond lengths, bond angles, dihedral angles, electronegativity (χ), chemical potential (μ), global hardness (η), softness (σ) and the electrophilicity index (ω). The thermal decomposition of the prepared metals complexes was studied by TGA, DTA and DSC techniques. Thermogravimetric studies revealed the presence of lattice or coordinated water molecules in all the prepared complexes. The decomposition mechanisms were suggested. The thermal decomposition of the complexes ended with the formation of metal oxides and carbon residue as a final product except in case of Hg complex, sublimation occur at the temperature range 376.5–575.0°C so, only carbon residue was produced during thermal decomposition. The orders of chemical reactions (n) were calculated via the peak symmetry method and the activation parameters were computed from the thermal decomposition data. The geometries of complexes may be converted from Oh to Td during the thermal decomposition steps.