Abstract
This work aims to characterize, synthesize and evaluate the biological activity of sodium barbitone and their metal chelates Ni(II), Pd(II) and Pt(II). The new synthesized metal chelates are investigated by elemental analysis, IR, mass spectra, thermal analysis and biological activity. Square planer structure of the prepared complexes obtained from the result of analysis. The antibacterial and antifungal of sodium barbitone ligand and its conforming metal chelates were screened against bacterial species Gram positive (Staphylococcus aureus), Gram negative bacteria (Escherichia coli) and fungi Aspergillus flavus and Candida albicans fungi. Ampicillin and amphotericin were used as references for antibacterial and antifungal studies. The activity data show that the platinum group metals chelates have activity data show that some of the platinum group metals (viz. Pt(II) and Pd(II)) chelates have a promising biological activity comparing to sodium barbitone parent free ligand against bacterial and fungal species.
Highlights
Sodium barbitone 5,5-diethyl barbiturate derived from barbituric acid belongs to the family of 2,4-pyrimidione, is prepared by the neutralization of an aqueous solution of lactam with sodium hydroxide and precipitating the salt by the addition of alcohol (Scheme 1)
The new synthesized metal chelates are investigated by elemental analysis, IR, mass spectra, thermal analysis and biological activity
The activity data show that the platinum group metals chelates have activity data show that some of the platinum group metals (viz. Pt(II) and Pd(II)) chelates have a promising biological activity comparing to sodium barbitone parent free ligand against bacterial and fungal species
Summary
Sodium barbitone 5,5-diethyl barbiturate derived from barbituric acid belongs to the family of 2,4-pyrimidione, is prepared by the neutralization of an aqueous solution of lactam with sodium hydroxide and precipitating the salt by the addition of alcohol (Scheme 1). Sodium barbital solutions have been used as pH buffers for biological research, e.g., in immunoelectrophoresis or in fixative solutions [3] [4]. The coordination chemistry of organotransition-metal complexes which have biologically active ligands has attracted tremendous interest over the years. The study of this complexes enable us understanding the role of these ligands in biological systems, in many biological systems compounds which containing pyrimidine ring play an important role, where they exist in nucleic acids, several vitamins, coenzymes and antibiotics [6] [7]. The metal complexes of pyrimidine widely taught owing to their great variety of biological activity ranging from antimalarial, antibacterial, antitumoral, antiviral activities etc. The metal complexes of pyrimidine widely taught owing to their great variety of biological activity ranging from antimalarial, antibacterial, antitumoral, antiviral activities etc. [9]-[15]
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