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Abstract
The incidence of multiple primary malignant neoplasms increases with age, reflecting an increase in overall cancer risk in older patients. Cases of two or more concurrent primary cancers are still rare, although its incidence is increasing. Here, we report the case of a 57-year-old man who was referred to our institution with synchronous squamous cell carcinoma of the skin on the forehead, infiltrating ductal carcinoma of the breast, and transitional cell carcinoma of the urinary bladder. To the best of our knowledge, this is the first reported case in literature of this combination of primary neoplasms.
Highlights
Multiple primary cancers (MPC) in a single patient was first documented by Billroth et al in 1889 [1]
We describe the case of a patient who developed synchronous primary transitional cell carcinoma (TCC) of the urinary bladder, squamous cell carcinoma (SCC) of the skin on the forehead, and infiltrating ductal breast carcinoma
Three primary and histologically distinct cancers were found in three different organs, that is, primary TCC of the urinary bladder, SCC of the skin on the forehead, and infiltrating ductal carcinoma of the breast, all within a 2-month period
Summary
Multiple primary cancers (MPC) in a single patient was first documented by Billroth et al in 1889 [1]. We describe the case of a patient who developed synchronous primary transitional cell carcinoma (TCC) of the urinary bladder, squamous cell carcinoma (SCC) of the skin on the forehead, and infiltrating ductal breast carcinoma. This combination, to the best of our knowledge, has never previously been reported in the literature. The nodular skin lesion was completely resected, and histopathological examination revealed it to be a SCC (grade II), infiltrating the hypodermis (Figure 2) After these surgical procedures, the patient was hospitalised in our institution where a cystoscopy was performed confirming ultrasound findings of multiple bladder papillary lesions arising from the posterior-lateral left wall, with a large base plant and active bleeding. He is currently receiving adjuvant chemotherapy, including gemcitabine and cisplatin
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