Signet-Ring Cell Carcinoma of the Urinary Bladder: A Review and Update

Anthony Kodzo-Grey Venyo

doi:10.31579/2640-1053/081

Abstract

Signet-Ring Cell Carcinoma of the Urinary Bladder: A Review and Update

Highlights

Signet-ring cell carcinoma of the urinary bladder is an uncommon histopathology variant of adenocarcinoma of the urinary bladder that tends to be characterised by the production of mucus and presence of signet-ring appearance of the tumour cells on histopathology examination of the tumours in which the nuclei of the tumour cells are pushed to the periphery of the tumour cells
To confirm whether a signet-ring cell carcinoma of the urinary bladder is a pure primary tumour or metastatic tumour does require detailed history taking with evidence of previously treated signet-ring cell carcinoma elsewhere and comparing the pathology features of the tumours, the undertaking of radiology imaging including ultrasound scan, computed tomography scan or magnetic resonance imaging scan of abdomen and pelvis as well as upper gastrointestinal endoscopy and lower gastrointestinal endoscopy to ascertain if there are any lesions within the gastrointestinal tract and taking biopsies of any suspicious lesion found for pathology examination and comparing the features of the lesions with the urinary tract tumours
There is an anecdotal report of an effective treatment of an advanced metastatic primary signet-ring cell carcinoma of the urinary bladder with utilization of docetaxel which resulted in destruction of the tumour cells without an operation which would indicate that some chemotherapy agents could be good enough for the successful treatment of signet-ring cell carcinomas of the bladder including primary and metastatic tumours

Summary

Introduction

Signet-ring cell carcinoma of the urinary bladder is an uncommon histopathology variant of adenocarcinoma of the urinary bladder that tends to be characterised by the production of mucus and presence of signet-ring appearance of the tumour cells on histopathology examination of the tumours in which the nuclei of the tumour cells are pushed to the periphery of the tumour cells. Primary Signet ring-cell carcinoma (SRCC) of the urinary bladder is said to be a relatively uncommon subtype of adenocarcinoma which has stated been to comprise only of 0.5% to 2% of primary carcinomas of the urinary bladder [1]. Considering that signet-ring cell carcinoma of the urinary bladder, whether it is a primary or metastatic tumour is an uncommon tumour, it would important for clinicians to have an overview background knowledge of signet-ring cell carcinomas generally and about signet-ring cell carcinomas of the urinary bladder in order to be up to date with the diagnosis and management of signet-ring cell carcinomas of the urinary bladder whether primary or metastatic. The ensuing article has been divided into two parts: (A) Overview which has discussed various general aspects of signet-ring cell carcinomas affecting other organs and the urinary bladder and (B) Miscellaneous narrations and discussions from some case reports, case series and studies related to signet-ring cell carcinoma of the urinary bladder

Methods

Findings

Summary and Conclusions