Abstract
External Urethral Orifice Metastasis of Cervical Cancer Treated With Intraluminal Urethral Brachytherapy Using a Lumencath Applicator: The First Case Report
Highlights
Cervical cancer is the fourth most common malignancy in women worldwide, with more than 300,000 deaths reported in 2018 [1]
Based on the clinical findings, we reviewed magnetic resonance imaging (MRI) findings again, and found an early enhanced effect on the external urethral orifice similar to the cervix and vagina (Figure 2C-D)
Considering tumor involvement, the CTVvagina was contoured by the entire vagina with a 5-mm margin from the surface of the Cylinder applicator and the CTVurethra was contoured by the entire urethra with a 2-mm margin from the surface of the Foley catheter from the external urethral orifice to the bladder neck
Summary
Cervical cancer is the fourth most common malignancy in women worldwide, with more than 300,000 deaths reported in 2018 [1]. Considering tumor involvement, the CTVvagina was contoured by the entire vagina with a 5-mm margin from the surface of the Cylinder applicator and the CTVurethra was contoured by the entire urethra with a 2-mm margin from the surface of the Foley catheter from the external urethral orifice to the bladder neck. The total biologically equivalent doses in 2 Gy fractions (EQD2) of EBRT (30.6 Gy/17 fractions) plus HDR-BT (24 Gy/4 fractions) based on the linear-quadratic model for CTV D90 of the cervix, vagina, and urethra were 72.5 Gy, 62.5 Gy, and 59.8 Gy, respectively, assuming an α/β ratio of 10. We achieved excellent local control for both primary tumor and external urethral orifice metastasis of cervical cancer (Figure 6). No tumor recurrence and grade ≥2 late toxicities were observed during the 15-month follow-up
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