Abstract
Galanin-like peptide (GALP) was discovered in 1999 in the porcine hypothalamus and was found to be a 60-aa neuropeptide. GALP aa residues at positions 9–21 of GALP share sequence homology with those at positions 1–13 of galanin. GALP can bind to, as well as activate, the three galanin receptor subtypes (GalR1–3). GALP is expressed in the arcuate nucleus, and GALP-containing neurons are targets for the action of leptin. GALP-producing neurons make neuronal networks with several feeding-related peptide-producing neurons. GALP has been proposed to play a role in the regulation of food intake behavior and body weight, and also regulates reproduction and thermogenesis. GALP may be of therapeutic value for obesity and lifestyle related diseases in the future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
