Abstract
Galanin-like peptide (GALP) was discovered in 1999 in the porcine hypothalamus and was found to be a 60-aa neuropeptide. GALP aa residues at positions 9–21 of GALP share sequence homology with those at positions 1–13 of galanin. GALP can bind to as well as activate the three galanin receptor subtypes (GalR1–3). GALP is expressed in the arcuate nucleus, and GALP-containing neurons are targets for the action of leptin. GALP-producing neurons make neuronal networks with several feeding-related peptide-producing neurons. GALP has been proposed to play a role in the regulation of food intake behavior and body weight, and also regulates reproduction and thermogenesis. GALP may be of therapeutic value for obesity and lifestyle related diseases in the future.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
