Study on Xingnaojing injection in treating patients with acute cerebral infarction and intervention effect on serum MMP-9, NO and NOS

Abstract

Objective To study the clinical effect of Xingnaojing injection in treating patients with acute cerebral infarction and its influence on serum matrix metalloproteinase 9 (MMP-9), nitric oxide (NO) and nitric oxide synthase (NOS). Methods 112 patients with acute cerebral infarction were randomly divided into two groups by random number table method, 56 cases in each group.The control group received routine treatment for acute cerebral infarction.The observation group received routine treatment plus intravenous injection Xingnaojing.The changes of NIHSS score, motor function score and sensory function score in the two groups were compared before and after treatment.The serum levels of MMP-9, NOS and NO in the two groups were observed before and after treatment. Results The total effective rate of observation group was 82.14%, which was significantly higher than 64.29% in the control group (χ2=4.553, P<0.05). After treatment, NIHSS scores of the observation group were significantly lower than the control group (t=5.082, 5.522, 6.253, all P<0.01). After treatment for 3 weeks, the motor function score (69.54±17.82)points, sensory function score (30.58±7.94) points of the observation group were significantly higher than (52.93±14.66)points and (23.08±6.31) points in the control group (t=5.387, 5.534, all P<0.01). After treatment, the serum MMP-9, NOS, NO levels of the observation group were significantly lower than the control group (all P<0.01). Conclusion Xingnaojing injection in the treatment of acute cerebral infarction has good curative effect, it can promote the recovery of neurological function, improve motor function and sensory function, and by adjusting the MMP-9, NOS, NO levels to protect the nerve and blood vessel function. Key words: Brain Infarction; Xingnaojing injection; Nerve function; Matrix metalloproteinase 9; Nitric oxide; Nitric oxide synthase