Effect of urinary kallidinogenase for injection on neurological function and serum matrix metalloproteinase 9 in patients with acute cerebral infarction

Abstract

Objective To investigate the effect of urinary kallidinogenase for injection on neurological function and serum matrix metalloproteinase 9 (MMP-9) in patients with cerebral infarction.Methods Ninety patients of acute cerebral infarction were divided into observation group and control group by random digits table with 45 cases each.The control group was treated with conventional therapy.The observation group was treated with conventional therapy and additional urinary kallidinogenase for injection treatment,0.15 PNA U/day,for 10 days.National institutes of health stroke scale (NIHSS) score and Barthel index (BI) score were used to evaluate the neurological impairment and the abilities of activities of daily living.The serum MMP-9 levels was tested by enzyme linked immunosorbent assay.The treatment outcome,NIHSS score,BI score and serum MMP-9 level were compared.Results The total effective rate in observation group [ 88.9％ (40/45) ] was higher than that in control group [ 71.1％ (32/45) ],and there was significant difference (P ＜ 0.05).NIHSS score after 3 months treatment was decreased and BI score was increased compared with before treatment in two groups,and there were significant differences(P＜ 0.05).NIHSS score after 3 months treatment in observation group [ (6.56 ± 0.74) scores] was lower than that in control group [ (9.06 ± 0.87 ) scores ],and there was significant difference (P ＜ 0.05 ).BI score after 3 months treatment in observation group [ (79.98 ± 7.32) scores ] was higher than that in control group [ (72.57 ± 6.95 ) scores ],and there was significant difference (P ＜ 0.05).Compared with before treatment,the serum MMP-9 level after 10 days treatment was significantly decreased in two groups (P＜ 0.05 ).The serum MMP-9 level after 10 days treatment in observation group[ ( 187.58 ± 14.52) ng/L] was lower than that in control group[ (238.89 ± 17.48 ) ng/L ] with significant difference (P ＜ 0.05 ).Conclusions Urinary kallidinogenase for injection can significantly improve neurological function in patients with cerebral infarction,significantly decrease serum MMP-9 levels.It has good effect and high clinical value. Key words: Matrix metalloproteinase 9; Brain infarction; Urinary kallidinogenase