Effects of olracitam on neurological function and serum TIMP-1 and MMP-9 levels in patients with hypertensive cerebral hemorrhage

Abstract

Objective To investigate the effect of olacetam on neurofunction and serum metalloproteinase-1 (TIMP-1) level and matrix metalloproteinase-9 (MMP-9) level of patients with hypertensive cerebral hemorrhage. Methods A total of 102 cases of hypertensive intracerebral hemorrhage treated in Liaocheng Third People’s Hospital from October 2016 to September 2018 were selected. According to the random number table method, the patients were divided into observation group (51 cases) and control group (51 cases). The control group was treated with nerve growth factor, and the observation group was treated with olracitam on the basis of the control group. The total effective rate of the two groups was compared with the National Institute of Health stroke scale (NIHSS) score, TIMP-1 level, MMP-9 level and adverse reactions during the treatment. Results At the end of treatment, the total effective rate of the observation group (98.04%) was higher than that of the control group (84.31%), and the difference was statistically significant (P 0.05). Conclusions Olracetam has a significant clinical effect in the adjuvant treatment of hypertensive cerebral hemorrhage, which can effectively improve the neurological function of patients, reduce the serum TIMP-1 and MMP-9 levels, with less complications. Key words: Hypertension; Cerebral hemorrhage; Olathe; Nerve growth factor; Nerve function