Study on the effect and safety of Shugan Jieyu capsules combined with olanzapine tablets for depressive symptoms in patients with schizophrenia

Abstract

Objective To study the effect and safety of Shugan Jieyu capsules combined with olanzapine tablets in the treatment of schizophrenia, and to analyze its effects on the patients' depressive symptoms. Methods According to the digital table, 80 patients with schizophrenia were randomly divided into control group and observation group, 40 cases in each group.The control group was treated with olanzapine, while the observation group was given olanzapine combined with Shugan Jieyu capsules.During the treatment, the other antidepressants, antipsychotics and mood stabilizers were prohibited. Results After treatment, the scores of CDSS, PANSS, PSQI and SQLS in the two groups were improved, and the differences were statistically significant(all P 0.05), and there were no significant differences between the two groups(all P>0.05). After treatment, the total effective rate of the control group(67.5%) was lower than 85.0% of the observation group, the difference was statistically significant(χ2=4.267, P 0.05). Conclusion For the treatment of schizophrenia, combined therapy of olanzapine tablets and Shugan Jieyu capsules has significant effect and higher safety, it can improve the patients' depressive symptoms, regulate the body's metabolism and improve their sleep and life quality. Key words: Schizophrenia; Depression; Shugan Jieyu capsules; Olanzapine