Study on the correlation of C-reactive protein level and cerebral hemorrhage prognosis

Abstract

Objective To analyze the correlation of C-reactive protein level and acute cerebral hemorrhage prognosis, provide the evidence for determining the condition and prognosis. Methods 163 patients with acute spontaneous intracerebral hemorrhage met selection criteria in Yantai Economic and Technology Development Area Hospital were selected as the study objects, the CRP were detected by immunoturbidimetry in the 1 day,3 days,7 days,14 days after admission,the NIHSS were calculated,48 cases of healthy people were selected as the control group, the CRP between hemorrhage group and the healthy control group, patients with different brain hemorrhage, patients with different neurological deficit were compared. Results (1)The C-reactive protein of cerebral hemorrhage group when admission were(8.92±1.0)mg/L,the control group were(4.25±0.23)mg/L,the C-reactive protein of cerebral hemorrhage group were significantly higher than that of the control group, the difference was statistically significant,t=-3.683,P<0.01.(2)The mean serum CRP after admission admission 1,3,7,14d were(9.34±1.65)mg/L,(9.56±1.58)mg/L,(6.58±1.17)mg/L,(4.98±1.26)mg/L,the CRP was a large rise in the course of the disease 1d,3d peak, F=7.487,P<0.05,the CRP had difference between large amount of brain hemorrhage,moderate amount of brain hemorrhage,and small amount of brain hemorrhage,a large amount of patients with cerebral hemorrhage CRP levels were higher than a moderate amount of patients with cerebral hemorrhage and a small amount of patients with cerebral hemorrhage 1,3 and 7d,during which the difference was statistically significant(F=3.31,4.62,4.21,P<0.01 or P<0.05).(3)The CRP peak levels of different degrees of neurological deficits in patients with acute cerebral hemorrhage decreased in 3d,7d,14d,the CRP of 3d were higher than that in 1d,the CRP of 7,14d were lower than that in 1d,CRP levels between different neurological deficits degree of acute cerebral hemorrhage were also significantly different(F=4.29,5.32,3.62,3.21,P<0.05 or P<0.01),the CRP levels of Severe neurological deficit in 1d,3d,7d,14d were significantly higher in mild and moderate neurological deficit(t=6.567,4.241,4.010,3.511 and 4.965,3.031,3.104,3.009,P<0.05 or P<0.01). Conclusion The serum CRP levels of patients with acute cerebral hemorrhage significantly increased, the serum CRP level shows dynamic changes in the first three days of the onset of peak, the CRP levels significantly correlated with the prognosis of cerebral hemorrhage, the more severe neurological deficit, the greater the amount of cerebral hemorrhage, higher serum CRP levels. Key words: Cerebral hemorrhage; C-reactive protein; Prognosis; Correlation