Influence of edaravone on inflammatory cytokines and oxidative stress products in patients with acute cerebral hemorrhage

Abstract

Objective To investigate the influence of edaravone on inflammatory cytokines and oxidative stress products in patients with acute cerebral hemorrhage. Methods From September 2014 to December 2016, 120 patients with acute cerebral hemorrhage in the People's Hospital of Gaomi were chosen and divided into control group and research group according to the digital table, with 60 cases in each group.The two groups were treated with dehydration, reducing intracranial pressure, improving the metabolism of brain tissue and other conventional treatment.The research group was treated with edaravone on the basis of routine treatment.After treatment for 2 weeks, the clinical effects, inflammatory cytokines, SOD, nerve function and life ability between the two groups were compared. Results The total effective rate of the research group was higher than that of the control group(90.00% vs.80.00%), but the difference was not statistically significant (χ2=2.353, P>0.05). Before treatment, the levels of inflammatory cytokines between the two groups had no statistically significant differences(t=0.061, 0.152, 0.698, 0.309, 0.146, 0.148, all P>0.05). After treatment, the levels of tumor necrosis factor alpha(TNF-α), interleukin 6(IL-6), C reactive protein(CRP), endothelin(ET), interleukin 8(IL-8) and interleukin 1 beta(IL-1 beta) in the research group were (34.48±8.93)μg/L, (41.83±13.86)μg/L, (27.56±4.73)mg/L, (3.15±0.72)μg/L, (24.83±7.51)ng/L, (9.75±3.16)ng/L, respectively, which were lower than those in the control group[(45.08±9.76)μg/L, (56.87±14.62)μg/L, (36.37±5.81)mg/L, (4.76±1.12)μg/L, (38.89±8.34)ng/L, (14.72±4.43)ng/L], the differences were statistically significant (t=6.207, 5.783, 9.109, 9.366, 9.704, 7.075, all P 0.05). After treatment, the levels of superoxide dismutase(SOD) and malondialdehyde(MDA) of the research group were (61.49±5.47)U/mL, (2.81±0.43)mol/L, respectively, which were lower than those in the control group[(72.53±4.84)U/mL, (3.67±0.49)mol/L], the differences were statistically significant (t=11.708, 10.218, all P<0.05). After treatment, the daily activity scale(ADL), the National Institutes of Health Stroke Scale(NIHSS) of the research group were (63.85±5.74), (4.75±2.04), which of the control group were (55.63±6.78), (7.46±2.17), respectively, the differences were statistically significant (t=7.048, 7.167, all P<0.05). Conclusion Edarvone has good control effects on inflammation and oxidative stress reaction, it is conducive to the improvement of neurological function and life ability. Key words: Cerebral hemorrhage; Edaravone; Inflammatory cytokines; Superoxide dismutase