Effect and mechanism of ginkgolide injection combined with edaravone on acute cerebral infarction

Abstract

Objective To evaluate the effect and mechanism of ginkgolide injection combined with edaravone on acute cerebral infarction. Methods 120 acute cerebral infarction patients were divided into observation group and control group, 60 cases in each group.The control group was treated with edaravone, and the observation group was treated with ginkgolide injection combined with edaravone.The neuron specific enolase(NSE), S100β, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C reactive protein(CRP), National Institutes of Health stroke scale(NIHSS) and clinical efficacy were compared between the two groups. Results After treatment, the levels of NSE, S100β, CRP, IL-6 and TNF-α of the observation group were (7.1±1.5)μg/L, (0.2±0.1)μg/L, (14.5±3.7)mg/L, (20.9±5.3)ng/L and (11.2±3.0)μg/L, respectively, which of the control group were (8.9±2.0)μg/L, (0.4±0.2)μg/L, (21.3±4.2)mg/L, (29.7±3.2)ng/L and (18.8±3.6)μg/L, respectively, those of the observation group were significantly lower than control group(t=2.898, 2.894, 3.012, 2.998, 3.025, all P<0.05). After treatment for 7d and 14d, the NIHSS scores of the observation group were (11.8±3.0)points and (7.3±2.2)points, respectively, which of the control group were (15.2±3.9)points and (10.5±3.0)points, respectively, the observation group were significantly lower than control group(t=2.984, 3.037, all P<0.05). The clinical efficacy of the observation group was significantly better than that of the control group(83.3% vs.61.7%)(χ2=7.064, P<0.05). Conclusion Ginkgolide injection combined with edaravone in the treatment of acute cerebral infarction can inhibit inflammation reaction, alleviate nerve function damage, its effect is better than edaravone. Key words: Ginkgolide injection; Edaravone; Brain infarction; Inflammation reaction