Study of Mean Platelet Volume in Individuals Suffer from Acute Appendicitis in Comparison with Healthy Ones

Abstract

BackgroundThe aim of this study was to evaluate the mean platelet volume (MPV) levels in patients with acute appendicitis in comparison with healthy people referring to educational hospitals of Kerman University of Medical Sciences.Materials and MethodsThis case-control study was conducted on 150 patients (75 cases, 75 controls). The inclusion criteria were aged over 15 years old who had undergone abdominal pain and appendicitis diagnosis. The number of white blood cells, percentage of neutrophils, MPV and C-Reactive Protein were checked. The control group included individuals who were referred for elective surgery after age and gender adaptation with the control group, complete blood count and MPV were checked for them. Finally, the data were analyzed by SPSS 25.ResultsThe results of this study showed that MPV level in the case group was 7.1±1.68 and in the control, the group was 9.8±1.17, which was significantly lower in the case group (P-value=0.001). The sensitivity and specificity of MPV in detecting acute appendicitis were 81% and 87% which were statistically significant.ConclusionOverall, the results of this study showed that MPV is considered as an important parameter in the diagnosis of acute appendicitis. It is essential that more studies be done to find specific and reliable biomarkers for their use in detecting acute appendicitis.