Study of antimicrobial qualities of antiseptic remedies, which contain decamethoxin

Abstract

In the research the effectiveness of antiseptic remedies, which contain decamethoxin® (DCM). Microbicidal (Pilot Manufacturing of Institute of Organic Chemistry of National Academy of Sciences of Ukraine) and its remedies’ forms (auridexan (AU), horosten® (HS), decasan® (DS), septefril (SF). The study was carried out on clinical strains of S. aureus (n 85), E. coli (n 22), P. aeruginosa (n 16), C. albicans (n 12) and was compared with museum strains, got from the museum of alive microbe cultures of Vinnytsya National Pirogov Memorial Medical University. Antimicrobial qualities of antiseptics were studied by means of serial dilutions method. The results of antimicrobial activity of remedies was analysed by minimal cidal concentration (МСС). We found, that DCM® (MCC – 3,67±2,71 mkg/ml), HS® (3,44±1,60 mkg/ml, DS® (3,06±1,95 mkg/ml), SF (4,32±2,47 mkg/ml) had their microbicidal activity against clinical strains of S. aureus. Such remedies of generic DCM® asAU, HS®, DS were found to have no difference in antimicrobial activity (р<0,05). Antimicrobial activity of DCM® (MCC – 26,8±17,5 mkg/ml) and its remedies horosten®, septefril on clinical strains of E. coli was significantly alike antimicrobial activity of museum strain of E. coli ATCC 25922 (MCC – 7,8 – 31,25 mkg/ml). clinical strains of P. aeruginosa were resistant to remedies of generic DCM® (MCC – 125-250 mkg/ml). C. albicans were sensitive to remedies of DCM® in cidal concentrations 3,9 – 31,25 mkg/ml. Effective antimicrobial qualities of generic decamethoxin® and its remedies (auridexan, horosten®, decasan®, septefril) are advisable to be used in fighting infection, caused by antibiotocresistant strains of S. aureus, E. coli, C. albicans.