Abstract
The substantiation of the method for introduction of lysozyme hydrochloride and ascorbic acid in the composition of the medicated chewing gum “Lysodent C”
Highlights
According to the results of pharmacotechnological studies, the substance of ascorbic acid has a satisfactory flowability, the composition of Health in Gum® (HiG) brand PWD-01 has good flowability, and lysozyme hydrochloride – acceptable flowability, which provides for the adjustment of this indicator
Based on the studies conducted, it has been determined that the rational way of lysozyme hydrochloride administering to the composition of medicated chewing gums using pre-granulation technology, and ascorbic acid by premixing with lysozyme granulate and chewable base to avoid oxidation of the substance at contact with the moisturizer
Marc Ribé // As appeared in Tablets & Capsules
Summary
The substantiation of the method for introduction of lysozyme hydrochloride and ascorbic acid in the composition of the medicated chewing gum “Lysodent C”. In recent years, medicated chewing gums have been widely distributed as a drug delivery system. The Industrial Technology of Drugs Department of NUPh develops compressed chewing gums under the conventional name “Lysodent C” for the prevention and treatment of dental diseases, in which as active pharmaceutical ingredients ascorbic acid and lysozyme hydrochloride are used, and as a chewable base – composition Health in Gum® of brand PWD-01 (Cafosa, Spain). Aim. To study the physico-chemical and pharmacotechnological properties of active pharmaceutical ingredients and chewable base for the purpose of establishing a method for the introduction of lysozyme hydrochloride and ascorbic acid into the composition of the compressed medicated chewing gums “Lysodent C”
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