Abstract
Alkylglycosides are biological surfactants used to solubilize membrane proteins. A large series of these compounds (commercial or synthesized) were chromatographed using reversed-phase liquid chromatography to study their amphiphilic properties. The latter were found to depend on the length of the alkyl chain, the nature of the polar head and the bonding nature between the sugar and alkyl chain. A comparison with hexaethylene glycol monoalkyl ethers was made. This chromatographic system with evaporative light-scattering detection allows excellent separations of all the compounds.
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