Abstract
A simple, rapid, accurate and precise assay procedure based on Spectrophotometric method has been developed for the estimation of Escitalopram oxalate (ESC) in Pharmaceutical formulation. The method was based on the bromination of ESC with a known excess amount of bromate-bromide mixture in acid medium followed by the determination of surplus bromine by reacting with dye methyl orange and measuring the absorbance at 507 nm. The proposed method was linear over the range of 2-14 μg/mL with the correlation co-efficient (r) of 0.9983 and the mean recovery for ESC was 100.5 %. The intermediate precision data obtained under different experimental setup, the calculated value of co-efficient of variance (CV, %) was found to be 1.14 % for both day to day and within a day variation. The proposed method can be successfully applied for the analysis of tablet formulations.
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