Abstract
ABSTRACTHere, we report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. Paired comparisons of the 13,335-nucleotide genomes revealed that the virus acquired the T10736C transition in its genome, which did not affect the amino acid sequences of HMPV proteins.
Highlights
We report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells
We found that upon propagation, HMPV acquired one point mutation in the viral genome
A T-to-C transition was found at position 10736 in P4. This variant resides in the open reading frame (ORF) of the L gene and does not affect the amino acid sequence of viral RNA-dependent RNA polymerase (RdRP)
Summary
We report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. We found that upon propagation, HMPV acquired one point mutation in the viral genome.
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