Abstract
Simultaneous Determination of Metformin and Pioglitazone in Presence of Metformin Impurity by Different Spectrophotometric and TLC – Densitometric Methods
Highlights
This method were validated and shown to demonstrate good accuracy and precision according to ICH guidelines
Metformin HCl (MET) is N; N dimethyl imido dicarbonimidic diamide hydrochloride .It is an antidiabitic drug from the biguanide class used in the management of type 2 diabetes
[3] MET and Pioglitazone HCl (PIO) combination is impartment for patients suffering from type 2 diabetes who require treatment with more than one anti-hyperglycemic drug to achieve optimal glycemic control [2]
Summary
This method were validated and shown to demonstrate good accuracy and precision according to ICH guidelines. Metformin HCl (MET) is N; N dimethyl imido dicarbonimidic diamide hydrochloride .It is an antidiabitic drug from the biguanide class used in the management of type 2 diabetes. The major action of Metformin is increasing glucose transport across the cell membrane in skeletal muscles [1]. Pioglitazone HCl (PIO) is (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy] benzyl]-2, 4-thiazolidinedione hydrochloride [2]. It is an anti-diabetic drug from the thiazolidinedione hydrochloride class of drugs [3] MET and PIO combination is impartment for patients suffering from type 2 diabetes who require treatment with more than one anti-hyperglycemic drug to achieve optimal glycemic control [2]. Melamine (MEL) is 1, 3, 5-Triazine-2, 4, 6-triamine; and it is a potential impurity of Metformin. The software is uv - pc personal spectroscopy version 3.7
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